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Current ResearchAngiogenesis/Heart When the arteries that deliver blood to your heart muscle, called coronary arteries, are narrowed or blocked, your body will secrete VEGF or FGF to grow new collaterals. These new arteries will deliver blood flow to the areas that are compromised. In some patients new collaterals supply enough blood to meet the demands of the heart. In others, they do not. These new genetically engineered growth factors show great promise in improving the blood supply to the heart of patients with coronary artery disease.
Angiogenesis/Leg Peripheral arterial occlusive disease (PAOD), aka: critical limb ischemia, is a closure or obstruction in a peripheral artery, such as in a limb, which prevents oxygenated blood from reaching the tissues. MMRF investigators are assessing the clinical effect of the treatment and safety of the gene FGF-1 given by intramuscular injections into the affected leg of patients with PAOD.
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