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Current ResearchThe Women's Health Initiative The Woman's Health Initiative (WHI) is one of the largest clinical studies of women and their health. This 15-year study involves approximately 150,000 postmenopausal women across the United States. The Berman Center for Outcomes and Clinical Research is studying 4,800 Minnesota women, between the age of 50 and 79, to see how changes in diet, hormone therapy, vitamin D and calcium affect cancer, heart disease and bone strength. Hypertension The Berman Center for Outcomes and Clinical Research is currently involved in a large hypertension trial, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health in collaboration with the Department of Veterans Affairs and three pharmaceutical companies, the 6-year study will follow more than 40,000 patients who suffer more than one risk factor for heart disease. The study is actually composed of two complementary trials. One portion of the study will look at the effectiveness of newer antihypertensive drugs in reducing the incidence of heart disease. Another portion of the study is trying to determine whether reducing cholesterol in patients with moderately high cholesterol reduces their death rate. The Center is also involved in a 4-year study (TROPHY) looking at the feasibility of preventing the development of high blood pressure, a major risk factor for death and heart disease. The study will determine if a new drug can reduce the incidence of hypertension in a population with high normal blood pressure. Heart Disease in Diabetics MMRF's Berman Center has been awarded a $12.6 million contract from the National Heart, Lung, and Blood Institute at the National Institutes of Health to help design and perform a historic study that will attempt to determine the best treatment for prevention of heart disease in persons with Type 2 diabetes. The Berman Center will oversee one of seven networks of clinics in the United States and Canada. Enrollment in the study will begin in mid 2000.
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