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Trauma
MMRF investigators are conducting drug studies to assess the safety and effectiveness of medications in treating a variety of conditions that can occur as a result of a traumatic injury. These conditions include sepsis, acute respiratory distress syndrome (ARDS) and nosocomial (not present or incubating at the time of hospital admission) pneumonia. In addition to testing potential treatments for trauma patients, MMRF researchers are working to unlock the secrets of mechanisms that trigger septic shock and multiple organ failure in an effort to improve the odds for patients suffering from these life-threatening conditions. Septic infection is the leading cause of death in noncoronary intensive care units, killing as many as 250,000 per year in the United States. Physicians have noticed that different people can have different responses to the same infectious problem. Most current therapies for septic infection assume that the white blood cells respond to a second infection the same way they respond to the first. Understanding different responses could lead to therapies that would be based on the precise immune state of each patient.
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